A 28-year-old woman presents to the renal clinic six weeks after a live-donor kidney transplant. She reports reduced urine output and mild graft tenderness. Creatinine has risen from 96 to 187 µmol/L. Ultrasound shows a normal-sized graft with no hydronephrosis. Graft biopsy demonstrates tubulitis with an interstitial mononuclear cell infiltrate. Which of the following is the most likely underlying mechanism?
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Question 1 of 10Nephrology